Peripheral surgical wounding may induce cognitive impairment through interlukin-6-dependent mechanisms in aged mice
نویسندگان
چکیده
منابع مشابه
Peripheral surgical wounding may induce cognitive impairment through interlukin-6-dependent mechanisms in aged mice
Post-operative cognitive dysfunction (POCD) is associated with morbidity, mortality and increased cost of medical care. However, the neuropathogenesis and targeted interventions of POCD remain largely to be determined. We have found that the peripheral surgical wounding induces an age-dependent Aβ accumulation, neuroinflammation and cognitive impairment in aged mice. Pro-inflammatory cytokine i...
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Post-operative cognitive dysfunction is associated with morbidity and mortality. However, its neuropathogenesis remains largely to be determined. Neuroinflammation and accumulation of β-amyloid (Aβ) have been reported to contribute to cognitive dysfunction in humans and cognitive impairment in animals. Our recent studies have established a pre-clinical model in mice, and have found that the per...
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ژورنال
عنوان ژورنال: Medical Gas Research
سال: 2016
ISSN: 2045-9912
DOI: 10.4103/2045-9912.196899